Angiotensin-converting enzyme (ACE) Antibody
299€ (50 µl)
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Name
Angiotensin-converting enzyme (ACE) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx402203
Tested Applications
ELISA, IHC
Description
Angiotensin-converting enzyme (ACE) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human ACE.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Angiotensin-converting enzyme (ACE) Immunogen: A synthesized peptide derived from human ACE1 |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P12821 |
| Alias | ACE1,CD143,DCP,DCP1,ICH,MVCD3 |
| Background | Antibody anti-ACE |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Angiotensin converting enzyme (ACE) is a pivotal enzyme in the Renin-Angiotensin-Aldosterone System (RAAS), a key regulator of blood pressure and fluid balance in the body. ACE plays a crucial role in converting angiotensin I to angiotensin II, a potent vasoconstrictor, thereby increasing blood pressure. ACE inhibitors are commonly prescribed medications that block this conversion, leading to vasodilation and reduced blood pressure. Apart from its role in blood pressure regulation, ACE also has functions in the metabolism of other peptides, including bradykinin. Dysregulation of ACE activity is associated with various cardiovascular diseases, such as hypertension, heart failure, and myocardial infarction. ACE inhibitors are widely used in the management of hypertension, heart failure, and certain kidney diseases. ACE gene polymorphisms have been linked to differences in individual responses to ACE inhibitors and susceptibility to cardiovascular diseases. Understanding the role of ACE has led to the development of novel therapeutic strategies targeting the RAAS for the treatment of cardiovascular disorders.
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