Angiomotin-Like Protein 1 (AMOTL1) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
Angiomotin-Like Protein 1 (AMOTL1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037664
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the AMOTL1 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Angiomotin-Like Protein 1 (AMOTL1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_570899.1 |
| Alias | JEAP |
| Background | Antibody anti-AMOTL1 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
Angiomotin Like 1 (AMOTL1) is a member of the angiomotin protein family, which is involved in regulating endothelial cell migration, polarity, and vascular stability. AMOTL1 plays a crucial role in maintaining endothelial barrier function and modulating angiogenesis by interacting with tight junction proteins and signaling pathways. It is known to participate in the regulation of the Hippo signaling pathway, where it influences cell proliferation and organ size by interacting with transcriptional regulators such as YAP and TAZ. AMOTL1 is also implicated in tumor progression, as it can modulate cell migration, adhesion, and invasion in cancer cells. Dysregulation of AMOTL1 has been associated with pathological angiogenesis, cancer metastasis, and inflammatory diseases. Its function in maintaining vascular integrity and its interaction with key signaling pathways make AMOTL1 a promising target for therapeutic interventions in vascular disorders and oncology.
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