The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
Primary Antibodies
Monoclonal
Human
Androgen Receptor (AR)
Mouse
Unconjugated
Liquid
ELISA
Unpurified ascites.
Ascitic fluid containing 0.03% sodium azide.
100 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
AR
No
Shipped within 5-10 working days.
KD,AIS,AR8,TFM,DHTR,SBMA,HYSP1,NR3C4,SMAX1,HUMARA,Dihydrotestosterone receptor,Nuclear receptor subfamily 3 group C member 4
This product is for research use only.
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