Anaphase-Promoting Complex Subunit 16 (ANAPC16) Antibody
357.5€ (100 µg)
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935106861
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name
Anaphase-Promoting Complex Subunit 16 (ANAPC16) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx038290
tested applications
ELISA, WB
Description
Rabbit Polyclonal against the ANAPC16 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Anaphase-Promoting Complex Subunit 16 (ANAPC16) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by Protein A/G column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_775744.1 |
| Alias | ANAPC16,C10orf104,CENP-27,Cyclosome subunit 16,APC16 |
| Background | Antibody anti-ANAPC16 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ANAPC16 is a structural and functional subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), where it contributes to the stability and assembly of the complex. ANAPC16 interacts with other core subunits to provide a scaffold for the APC/C, supporting its function as a critical E3 ubiquitin ligase during mitosis. It is involved in the targeting and ubiquitination of key regulators, including cyclin B, securin, and other proteins required for chromosome segregation and mitotic exit. ANAPC16 ensures proper APC/C activation and substrate recruitment, maintaining the progression of the cell cycle. Disruption or mutation of ANAPC16 leads to mitotic defects, genomic instability, and impaired cell proliferation, which are hallmarks of cancer development. ANAPC16’s role as a structural stabilizer underscores its importance in APC/C-mediated proteolysis and cell cycle progression.
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