Anaphase-Promoting Complex Subunit 11 (ANAPC11) Antibody

Este producto es parte de ANAPC - Anaphase-promoting complex subunit
Product Graph
442€ (200 µl)

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935106861
info@markelab.com
name
Anaphase-Promoting Complex Subunit 11 (ANAPC11) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432326
tested applications
P-ELISA, WB

Description

ANAPC11 Antibody is a Goat Polyclonal antibody against ANAPC11.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Target: Anaphase-Promoting Complex Subunit 11 (ANAPC11)
Immunogen: abx616112 - Internal region: PALDQETSSLLRCTS
Host
Goat
Reactivity
Human
Assay Type
Concentration: 0.5 mg/ml
Recommended Dilution
P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Size 1
200 µl
Form
Liquid
Tested Applications
P-ELISA, WB
Buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Gene ID
51529
NCBI Accession
NP_001002244.1, NP_057560.8
Alias
ANAPC11,HSPC214,Cyclosome subunit 11
Background
Antibody anti-ANAPC11
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

ANAPC11 is the catalytic RING finger subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), where it facilitates the ubiquitin transfer activity of the complex. As an E3 ubiquitin ligase, ANAPC11 directly interacts with E2 ubiquitin-conjugating enzymes to catalyze the ubiquitination of cell cycle regulators such as cyclin B and securin, promoting their degradation via the proteasome. This process is critical for initiating anaphase, regulating mitotic exit, and maintaining genomic stability. ANAPC11 is essential for APC/C activity, and its loss or inhibition results in mitotic arrest, aneuploidy, and cell cycle defects. Mutations or dysregulation of ANAPC11 have been associated with cancer progression, as impaired proteolysis of APC/C substrates can lead to uncontrolled proliferation and chromosomal instability. ANAPC11’s catalytic function makes it a central component of APC/C and a potential target for cancer therapies aimed at disrupting mitotic progression in tumor cells.
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abx616112
Anaphase-Promoting Complex Subunit 11 (ANAPC11) Peptide
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