Anaphase-Promoting Complex Subunit 11 (ANAPC11) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Anaphase-Promoting Complex Subunit 11 (ANAPC11) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230475
tested applications
ELISA, WB, IHC
Description
APC11 Antibody is a Rabbit Polyclonal against APC11.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Anaphase-Promoting Complex Subunit 11 (ANAPC11) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NYG5 |
| Alias | ANAPC11,HSPC214,Cyclosome subunit 11 |
| Background | Antibody anti-ANAPC11 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ANAPC11 is the catalytic RING finger subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), where it facilitates the ubiquitin transfer activity of the complex. As an E3 ubiquitin ligase, ANAPC11 directly interacts with E2 ubiquitin-conjugating enzymes to catalyze the ubiquitination of cell cycle regulators such as cyclin B and securin, promoting their degradation via the proteasome. This process is critical for initiating anaphase, regulating mitotic exit, and maintaining genomic stability. ANAPC11 is essential for APC/C activity, and its loss or inhibition results in mitotic arrest, aneuploidy, and cell cycle defects. Mutations or dysregulation of ANAPC11 have been associated with cancer progression, as impaired proteolysis of APC/C substrates can lead to uncontrolled proliferation and chromosomal instability. ANAPC11’s catalytic function makes it a central component of APC/C and a potential target for cancer therapies aimed at disrupting mitotic progression in tumor cells.
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