Amphiphysin (AMPH) Antibody
286€ (100 µl)
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name
Amphiphysin (AMPH) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130643
tested applications
WB, IHC, IF/ICC
Description
Amphiphysin Antibody is a Rabbit Polyclonal against Amphiphysin.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Amphiphysin (AMPH) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AMPH,AMPH1 |
| Background | Antibody anti-AMPH |
| Status | RUO |
Descripción
AMPH or Amphiphysin, is a protein that plays important roles in the nervous system, particularly in synaptic vesicle endocytosis and membrane trafficking. Amphiphysin is a cytosolic protein found in nerve terminals, especially in the brain. It belongs to a family of proteins that contain an N-terminal BAR (Bin-Amphiphysin-Rvs) domain, a central coiled-coil domain, and a C-terminal SH3 (Src homology 3) domain. One of the main functions of Amphiphysin is its involvement in synaptic vesicle endocytosis, a process crucial for maintaining neurotransmission at synapses. It helps in the formation of clathrin-coated vesicles, which are responsible for internalizing neurotransmitter-containing vesicles after they have released their contents into the synaptic cleft.The BAR domain of Amphiphysin allows it to sense and induce membrane curvature. This ability is important for its role in shaping membranes during vesicle formation and trafficking. Amphiphysin interacts with dynamin, another protein involved in vesicle formation and fission. This interaction is crucial for the scission of clathrin-coated vesicles from the plasma membrane during endocytosis
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Amphiphysin(AMPH), a synaptic vesicle-associated protein that is highly concentrated in nerve terminal, is an autoantigen of Stiff-Man syndrome with breast cancer. Amphiphysin contains a N-terminal BAR(Bin1/Amphiphysin/Rv167) domain followed by an endocytosis domain, and a C-terminal SH3 domain. Amphiphysin has been proposed to function as a linker between the clathrin coat and dynamin in the endocytosis of synaptic vesicles. It may also participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types.
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