Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) Antibody (Biotin)
403€ (200 µl)
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Name
Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx271863
Tested Applications
WB
Description
Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.5-2 µg/ml, IHC (Predicted): 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 200 µl |
| Size 2 | 1 ml |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | p43,HLD3,EMAP2,SCYE1,EMAPII |
| Background | Antibody anti-AIMP1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AIMP1, also known as EMAP II (Endothelial Monocyte-Activating Polypeptide II), is a multifunctional protein that acts as a core component of the multi-aminoacyl-tRNA synthetase complex (MSC), which is essential for protein synthesis. It interacts with various aminoacyl-tRNA synthetases to maintain the stability and functionality of the complex. Beyond its role in translation, AIMP1 has extracellular signaling functions, particularly in modulating immune responses and angiogenesis. When secreted, AIMP1 functions as a cytokine that activates monocytes and endothelial cells, contributing to inflammatory responses and tissue repair. It is also involved in apoptosis, cellular stress responses, and tumor suppression. Dysregulation of AIMP1 is associated with cancer progression, inflammatory diseases, and autoimmune disorders, highlighting its dual roles in intracellular protein synthesis and extracellular signaling.
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