Aminoacyl tRNA Synthase Complex-Interacting Multifunctional Protein 2 / JTV1 (AIMP2) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Aminoacyl tRNA Synthase Complex-Interacting Multifunctional Protein 2 / JTV1 (AIMP2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx214082
tested applications
ELISA, WB, IHC
Description
AIMP2 Antibody is a Rabbit Polyclonal against AIMP2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aminoacyl tRNA Synthase Complex-Interacting Multifunctional Protein 2 / JTV1 (AIMP2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, WB: 1/200 - 1/1000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13155 |
| Gene ID | 7965 |
| Alias | HLD17,JTV-1, JTV1,P38 |
| Background | Antibody anti-AIMP2 |
| Status | RUO |
Descripción
AIMP2 is a structural and regulatory protein that stabilizes the multi-aminoacyl-tRNA synthetase complex (MSC) and modulates various cellular processes, including translation, stress responses, and cell cycle regulation. AIMP2 interacts with other aminoacyl-tRNA synthetases to ensure the efficient attachment of amino acids to their corresponding tRNAs. In addition to its translational role, AIMP2 functions as a tumor suppressor, particularly through its isoform AIMP2-DX2, which inhibits cell proliferation and induces apoptosis. Dysregulation of AIMP2 is implicated in cancers, where loss of its tumor-suppressive activity promotes tumor growth and chemoresistance. It is also involved in neurodegenerative diseases such as Parkinson’s disease, where it modulates oxidative stress and neuronal survival. AIMP2’s role in both protein synthesis and cellular homeostasis underscores its importance in health and disease.
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