Alsin (ALS2) Antibody
357.5€ (100 µg)
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Name
Alsin (ALS2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx036694
Tested Applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ALS2 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Alsin (ALS2) Immunogen: Recombinant fragment corresponding to 177-414 AA of human ALS2. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 184 kDa, 43 kDa, 87 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ALS2,ALS2CR6 |
| Background | Antibody anti-ALS2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALS2, also known as Alsin, refers to a gene that encodes a protein called Alsin. Mutations in the ALS2 gene are associated with a rare autosomal recessive form of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, a progressive neurodegenerative disorder characterized by the degeneration of motor neurons in the brain and spinal cord. The ALS2 gene provides instructions for producing the Alsin protein, which is involved in various cellular functions, including the regulation of endosome trafficking, maintenance of the cytoskeleton, and protection against oxidative stress. Alsin is particularly important for the health and function of motor neurons, the nerve cells that control voluntary muscle movement. Mutations in the ALS2 gene can lead to dysfunctional or truncated forms of the Alsin protein, which can disrupt normal cellular processes and contribute to the degeneration of motor neurons seen in ALS. However, it's worth noting that ALS2 mutations are relatively rare and account for only a small percentage of ALS cases.
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