Alsin (ALS2) Antibody

Product specifications

Primary Antibodies

Alsin (ALS2)

Rabbit

Human, Mouse, Rat

ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified by affinity chromatography.

20 µl

100 µl

2 × 100 µl

Liquid

ELISA, WB, IF/ICC

PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

Q96Q42

57679

NP_065970.2

ALS2,ALS2CR6

Antibody anti-ALS2

RUO

Concentration: > 0.2 mg/ml - 

Descripción

ALS2, also known as Alsin, refers to a gene that encodes a protein called Alsin. Mutations in the ALS2 gene are associated with a rare autosomal recessive form of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, a progressive neurodegenerative disorder characterized by the degeneration of motor neurons in the brain and spinal cord. The ALS2 gene provides instructions for producing the Alsin protein, which is involved in various cellular functions, including the regulation of endosome trafficking, maintenance of the cytoskeleton, and protection against oxidative stress. Alsin is particularly important for the health and function of motor neurons, the nerve cells that control voluntary muscle movement. Mutations in the ALS2 gene can lead to dysfunctional or truncated forms of the Alsin protein, which can disrupt normal cellular processes and contribute to the degeneration of motor neurons seen in ALS. However, it's worth noting that ALS2 mutations are relatively rare and account for only a small percentage of ALS cases.

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anti- ALS2 antibody

May act as a GTPase regulator. Controls survival and growth of spinal motoneurons(By similarity).

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Alsin (ALS2) Antibody

ALS2 Antibody is a Rabbit Polyclonal antibody against ALS2. The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.

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Alsin (ALS2) Antibody

ALS2 Antibody is a Rabbit Polyclonal antibody against ALS2. The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.

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