Alpha-Protein Kinase 3 (ALPK3) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
Alpha-Protein Kinase 3 (ALPK3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037699
tested applications
ELISA, IHC
Description
Rabbit Polyclonal against the ALPK3 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Alpha-Protein Kinase 3 (ALPK3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96L96 |
| Alias | ALPK3,KIAA1330,MAK |
| Background | Antibody anti-ALPK3 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ALPK3 is an alpha-protein kinase involved in critical cellular processes, including cardiac development, sarcomere organization, and metabolic signaling. It is highly expressed in cardiac and skeletal muscle tissues, where it regulates protein phosphorylation necessary for proper contractile function and muscle structure. Mutations in ALPK3 are associated with cardiomyopathies, including dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), due to defects in sarcomere assembly and signaling pathways. ALPK3 has also been shown to interact with AMPK (AMP-activated protein kinase), linking it to energy sensing and metabolic regulation in cardiomyocytes. Beyond its role in cardiac function, ALPK3 may influence cell growth and differentiation, and its dysregulation has been implicated in tumorigenesis. Recent studies suggest that ALPK3 acts as a tumor suppressor in specific cancers, where its loss of function enhances cell proliferation and survival. Its critical roles in cardiac development and cellular metabolism make ALPK3 a promising target for therapeutic intervention in cardiac and metabolic diseases.
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