Aldolase C Antibody
364€ (100 µg)
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935106861
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name
Aldolase C Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230304
tested applications
ELISA, WB, IHC, IF/ICC
Description
Aldolase C Antibody is a Mouse Monoclonal against Aldolase C.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldolase C |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/5000 - 1/50000, IHC: 1/50 - 1/500, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09972 |
| Alias | ALDOC,ALDC |
| Background | Antibody anti-ALDOC |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ALDOC is a brain-specific isoform of fructose-bisphosphate aldolase that catalyzes the same glycolytic reaction as ALDOA and ALDOB, converting fructose-1,6-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. ALDOC is highly expressed in the central nervous system (CNS), particularly in astrocytes and Purkinje cells of the cerebellum, where it plays a key role in brain energy metabolism and glucose utilization. Altered expression or mutations in ALDOC are linked to neurodegenerative disorders and gliomas, where energy metabolism is disrupted. Additionally, ALDOC is involved in maintaining neuronal function and astrocyte homeostasis under normal and stress conditions. Its critical role in glycolysis makes it essential for supporting brain function and energy demands.
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anti- Aldolase C antibody
Fructose-bisphosphate aldolase C(ALDOC) reversibly cleaves FBP and F1-P to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate and is strongly expressed in mammalian brain together with ALDOA and is alsopresent in the heart and spleen of some species(PMID:9363598). It is involed in glycolysis as an important enzyme. Phospholipase D2 and inositol 1,4,5-triphosphate interact with ALDOC in signal transduction. Meanwhile, the protein expression of ALDOC has been reported to be regulated in brain tumor, hepatomas, and lung cancer(PMID:21548097).
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