Aldo-Keto Reductase Family 1 Member C1 (AKR1C1) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Aldo-Keto Reductase Family 1 Member C1 (AKR1C1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx148108
tested applications
ELISA, WB
Description
Aldo-Keto Reductase Family 1 Member C1 (AKR1C1) Antibody is a Rabbit Polyclonal antibody for the detection of AK1C1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldo-Keto Reductase Family 1 Member C1 (AKR1C1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q04828 |
| Gene ID | 1645 |
| OMIM | 600449 |
| Alias | AKR1C1,DDH,DDH1 |
| Background | Antibody anti-AKR1C1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
AKR1C1, also known as 20α-hydroxysteroid dehydrogenase, is an enzyme involved in the metabolism of steroid hormones, specifically converting progesterone to its inactive metabolite, 20α-dihydroprogesterone. It plays a critical role in maintaining hormone balance and modulating progesterone-dependent signaling pathways, particularly in reproductive tissues. AKR1C1 also participates in the metabolism of androgens, estrogens, and other steroid hormones, influencing cell proliferation and differentiation. Overexpression of AKR1C1 has been implicated in hormone-driven cancers, such as breast, ovarian, and prostate cancers, where it reduces active steroid hormone levels to promote tumor progression. AKR1C1 also metabolizes reactive aldehydes, such as 4-hydroxynonenal (4-HNE), protecting cells from oxidative stress and chemotherapeutic agents. Its involvement in drug resistance highlights AKR1C1 as a potential therapeutic target in cancer treatment. Additionally, AKR1C1 is linked to neurological functions, as it regulates neurosteroids that modulate synaptic transmission and neuroprotection.
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