Aldehyde Dehydrogenase 8 Family Member A1 (ALDH8A1) Antibody
260€ (50 µl)
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935106861
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name
Aldehyde Dehydrogenase 8 Family Member A1 (ALDH8A1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx213155
tested applications
ELISA, WB, IHC
Description
ALDH8A1 Antibody is a Rabbit Polyclonal against ALDH8A1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldehyde Dehydrogenase 8 Family Member A1 (ALDH8A1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, WB: 1/500 - 1/2000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H2A2 |
| Gene ID | 64577 |
| Alias | ALDH8A1,ALDH12 |
| Background | Antibody anti-ALDH8A1 |
| Status | RUO |
Descripción
ALDH8A1 is a cytosolic enzyme primarily involved in the metabolism of retinaldehyde to retinoic acid, a key signaling molecule that regulates cell differentiation, growth, and tissue homeostasis. ALDH8A1 is expressed in metabolic tissues, including the liver, kidneys, and retina, where it supports retinoid metabolism and vitamin A homeostasis. Its role in converting retinaldehyde to retinoic acid makes ALDH8A1 critical for maintaining vision, embryonic development, and immune responses. Dysregulation of ALDH8A1 has been implicated in retinal diseases, such as age-related macular degeneration (AMD), and developmental abnormalities caused by retinoic acid deficiency. ALDH8A1 also participates in detoxifying aldehydes derived from lipid peroxidation and xenobiotic metabolism, contributing to cellular defense against oxidative stress. Emerging studies suggest its involvement in maintaining retinoid signaling pathways and redox balance.
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