Aldehyde Dehydrogenase 1 Family Member L2 (ALDH1L2) Antibody
377€ (100 µg)
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Name
Aldehyde Dehydrogenase 1 Family Member L2 (ALDH1L2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx230290
Tested Applications
ELISA, WB, IHC
Description
ALDH1L2 Antibody is a Rabbit Polyclonal against ALDH1L2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aldehyde Dehydrogenase 1 Family Member L2 (ALDH1L2) Immunogen: aldehyde dehydrogenase 1 family, member L2 |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/200 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 89 kDa, 102 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q3SY69 |
| Gene ID | 160428 |
| OMIM | 613584 |
| Alias | Mitochondrial 10-FTHFDH |
| Background | Antibody anti-ALDH1L2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALDH1L2 is the mitochondrial isoform of 10-formyltetrahydrofolate dehydrogenase and plays a critical role in mitochondrial one-carbon metabolism. It catalyzes the oxidation of 10-formyltetrahydrofolate to CO2 and tetrahydrofolate, producing NADPH, which supports mitochondrial redox balance and biosynthetic processes. ALDH1L2 is essential for maintaining nucleotide synthesis, amino acid metabolism, and methylation pathways within the mitochondria, particularly during high energy and biosynthetic demands. Its function in producing NADPH also makes it critical for detoxifying reactive oxygen species (ROS) and protecting cells from oxidative stress. Dysregulation of ALDH1L2 has been implicated in metabolic diseases, neurodegenerative conditions, and cancer. In cancer, loss of ALDH1L2 contributes to metabolic reprogramming, where mitochondrial folate metabolism is disrupted to favor rapid proliferation and tumor growth. Recent studies indicate that ALDH1L2 could serve as a therapeutic target for rebalancing mitochondrial metabolism and reducing oxidative stress in cancer cells.
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