Aldehyde Dehydrogenase 1 Family Member L2 (ALDH1L2) Antibody
357.5€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Aldehyde Dehydrogenase 1 Family Member L2 (ALDH1L2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037113
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ALDH1L2 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldehyde Dehydrogenase 1 Family Member L2 (ALDH1L2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Mitochondrial 10-FTHFDH |
| Background | Antibody anti-ALDH1L2 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ALDH1L2 is the mitochondrial isoform of 10-formyltetrahydrofolate dehydrogenase and plays a critical role in mitochondrial one-carbon metabolism. It catalyzes the oxidation of 10-formyltetrahydrofolate to CO2 and tetrahydrofolate, producing NADPH, which supports mitochondrial redox balance and biosynthetic processes. ALDH1L2 is essential for maintaining nucleotide synthesis, amino acid metabolism, and methylation pathways within the mitochondria, particularly during high energy and biosynthetic demands. Its function in producing NADPH also makes it critical for detoxifying reactive oxygen species (ROS) and protecting cells from oxidative stress. Dysregulation of ALDH1L2 has been implicated in metabolic diseases, neurodegenerative conditions, and cancer. In cancer, loss of ALDH1L2 contributes to metabolic reprogramming, where mitochondrial folate metabolism is disrupted to favor rapid proliferation and tumor growth. Recent studies indicate that ALDH1L2 could serve as a therapeutic target for rebalancing mitochondrial metabolism and reducing oxidative stress in cancer cells.
Related Products
ALDH1L2 antibody
ALDH1L2(Aldehyde dehydrogenase family 1 member L2) is also named as mitochondrial 10-FTHFDH, mtFDH and belongs to the aldehyde dehydrogenase family and ALDH1L subfamily. The ALDH1L2 gene has three transcriptional variants with the molecular weight of 102 kDa, 42 kDa and 89 kDa(PMID:19823103).
Ver Producto
Recombinant Human ALDH1L2
Ver Producto
Aldehyde Dehydrogenase 1 Family Member L2 (ALDH1L2) Antibody
Rabbit Polyclonal against the ALDH1L2 protein.
Ver Producto