Aldehyde Dehydrogenase 1 Family Member L2 (ALDH1L2) Antibody
357.5€ (100 µg)
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Name
Aldehyde Dehydrogenase 1 Family Member L2 (ALDH1L2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx037113
Tested Applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ALDH1L2 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aldehyde Dehydrogenase 1 Family Member L2 (ALDH1L2) Immunogen: Recombinant fragment corresponding to 2-247 AA of human ALDH1L2. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 102 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Mitochondrial 10-FTHFDH |
| Background | Antibody anti-ALDH1L2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALDH1L2 is the mitochondrial isoform of 10-formyltetrahydrofolate dehydrogenase and plays a critical role in mitochondrial one-carbon metabolism. It catalyzes the oxidation of 10-formyltetrahydrofolate to CO2 and tetrahydrofolate, producing NADPH, which supports mitochondrial redox balance and biosynthetic processes. ALDH1L2 is essential for maintaining nucleotide synthesis, amino acid metabolism, and methylation pathways within the mitochondria, particularly during high energy and biosynthetic demands. Its function in producing NADPH also makes it critical for detoxifying reactive oxygen species (ROS) and protecting cells from oxidative stress. Dysregulation of ALDH1L2 has been implicated in metabolic diseases, neurodegenerative conditions, and cancer. In cancer, loss of ALDH1L2 contributes to metabolic reprogramming, where mitochondrial folate metabolism is disrupted to favor rapid proliferation and tumor growth. Recent studies indicate that ALDH1L2 could serve as a therapeutic target for rebalancing mitochondrial metabolism and reducing oxidative stress in cancer cells.
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