Alanine Glyoxylate Aminotransferase (AGXT) Antibody Pair
1170€ (5 × 96 tests)
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name
Alanine Glyoxylate Aminotransferase (AGXT) Antibody Pair
category
Antibody Pairs
provider
Abbexa
reference
abx370896
tested applications
ELISA
Description
Alanine Glyoxylate Aminotransferase (AGXT) Antibody Pair for use in Sandwich ELISA assay development. This antibody pair contains: Detection: 50 µg Capture: 200 µg Standard: 5 µg
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Antibody Pairs |
| Immunogen Target | Alanine Glyoxylate Aminotransferase (AGXT) |
| Host | Capture Host: Rabbit Detection Host: Rabbit |
| Reactivity | Human |
| Assay Data | Sandwich |
| Assay Type | Capture Antibody: 0.5 mg/ml Detection Antibody: 0.2 mg/ml Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user. For a standard curve range of 1.56 ng/ml - 100 ng/ml, a reconstitution volume of 1 ml is recommended. |
| Test Range | 1.56 ng/ml - 100 ng/ml |
| Recommended Dilution | Dilute the Capture Antibody 125-fold with Coating Buffer. Dilute the Detection Antibody 200-fold with Detection Antibody Diluent. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Capture Clonality: Polyclonal Detection Clonality: Polyclonal |
| Conjugation | Unconjugated |
| Size 1 | 5 × 96 tests |
| Size 2 | 10 × 96 tests |
| Form | Standard form: Lyophilized Capture Ab: Liquid Detection Ab: Liquid |
| Tested Applications | ELISA |
| Buffer | The Capture and Detection Antibody both contain 0.1% sodium azide. |
| Availability | Shipped within 5-20 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AGXT, AGT1, SPAT |
| Background | Antibody pair for AGXT |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Alanine-glyoxylate aminotransferase (AGXT) is a pyridoxal phosphate-dependent enzyme localized in peroxisomes, where it plays a critical role in detoxifying glyoxylate by converting it into glycine, using alanine as an amino donor. AGXT is central to preventing the overproduction of oxalate, a byproduct of glyoxylate metabolism, which, if accumulated, can form calcium oxalate crystals leading to kidney stones and renal damage. Mutations in the AGXT gene cause primary hyperoxaluria type 1 (PH1), a rare autosomal recessive disorder characterized by excessive oxalate production, kidney stone formation, and systemic oxalosis. AGXT's activity is regulated by intracellular localization and metabolic cues, and therapies targeting AGXT include enzyme replacement therapy and gene therapy to restore glyoxylate metabolism in affected individuals.
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