Alanine Glyoxylate Aminotransferase 2 (AGXT2) Antibody
299€ (100 µl)
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935106861
info@markelab.com
name
Alanine Glyoxylate Aminotransferase 2 (AGXT2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130620
tested applications
WB, IHC, IF/ICC
Description
AGXT2 Antibody is a Rabbit Polyclonal against AGXT2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Alanine Glyoxylate Aminotransferase 2 (AGXT2) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AGXT2, AGT2 |
| Background | Antibody anti-AGXT2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Alanine-glyoxylate aminotransferase 2 (AGXT2) is a mitochondrial enzyme that participates in the metabolism of amino acids, including the reversible conversion of glyoxylate and alanine to pyruvate and glycine. AGXT2 plays a role in cardiovascular health by metabolizing dimethylarginines, including asymmetric dimethylarginine (ADMA), an inhibitor of nitric oxide synthase and a biomarker for cardiovascular diseases. By reducing ADMA levels, AGXT2 contributes to the regulation of nitric oxide production and endothelial function. Dysregulation of AGXT2 is implicated in hypertension, atherosclerosis, and metabolic syndromes. In addition, AGXT2's role in glyoxylate metabolism links it to oxalate production, suggesting potential contributions to kidney stone formation and renal dysfunction in certain pathological contexts.
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