Alanine Glyoxylate Aminotransferase 2 (AGXT2) Antibody
357.5€ (100 µg)
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name
Alanine Glyoxylate Aminotransferase 2 (AGXT2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037655
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the AGXT2 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Alanine Glyoxylate Aminotransferase 2 (AGXT2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_114106.1 |
| Alias | AGXT2, AGT2 |
| Background | Antibody anti-AGXT2 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
Alanine-glyoxylate aminotransferase 2 (AGXT2) is a mitochondrial enzyme that participates in the metabolism of amino acids, including the reversible conversion of glyoxylate and alanine to pyruvate and glycine. AGXT2 plays a role in cardiovascular health by metabolizing dimethylarginines, including asymmetric dimethylarginine (ADMA), an inhibitor of nitric oxide synthase and a biomarker for cardiovascular diseases. By reducing ADMA levels, AGXT2 contributes to the regulation of nitric oxide production and endothelial function. Dysregulation of AGXT2 is implicated in hypertension, atherosclerosis, and metabolic syndromes. In addition, AGXT2's role in glyoxylate metabolism links it to oxalate production, suggesting potential contributions to kidney stone formation and renal dysfunction in certain pathological contexts.
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