AKT Interacting Protein (AKTIP) Antibody

Product specifications

Primary Antibodies

AKT Interacting Protein (AKTIP)

Rabbit

Human

IHC: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

> 95%

Purified by Protein G.

20 µg

50 µg

100 µg

200 µg

1 mg

Liquid

ELISA, IHC, IF/ICC

0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

Q9H8T0

64400

NP_001012398.1, NM_001012398.2

608483

AKTIP,FTS

Antibody anti-AKTIP

RUO

Descripción

AKT Interacting Protein (AKTIP) is a multifunctional protein that plays a role in the regulation of cellular proliferation, survival, and DNA repair by interacting with AKT, a serine/threonine kinase involved in key signaling pathways. AKTIP is implicated in the maintenance of telomere integrity and genomic stability by facilitating telomere replication and protecting telomeres from damage. It also functions in vesicular trafficking and lipid metabolism, linking it to processes such as endosome dynamics and cellular energy homeostasis. Dysregulation of AKTIP is associated with genomic instability, which can lead to cancer progression and age-related diseases. AKTIP is also being studied for its role in insulin signaling and metabolic disorders due to its interaction with the AKT pathway. Research into AKTIP continues to uncover its broader implications in cellular signaling and its potential as a therapeutic target in cancer and metabolic dysfunction.

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AKTIP antibody

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.

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AKT Interacting Protein (AKTIP) Antibody

AKTIP Antibody is a Rabbit Polyclonal antibody against AKTIP. The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.

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AKT Interacting Protein (AKTIP) Antibody

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB) /Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.

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