AKTIP - AKT Interacting Protein | Elisa - Clia - Antibody - Protein

Background:

AKTIP or AKT Interacting Protein is a protein that interacts with and modulates the activity of AKT (also known as Protein Kinase B), a key regulator of various cellular processes such as cell survival, proliferation, and metabolism. AKTIP was initially identified as a protein that interacts with AKT and influences its subcellular localization and activity. Research suggests that AKTIP can promote AKT phosphorylation and activation by facilitating its recruitment to the plasma membrane, where AKT exerts its downstream effects on various cellular processes. AKTIP has been also implicated in other cellular functions and signaling pathways. For example, it has been linked to the regulation of cell migration, invasion, and metastasis in cancer cells. Furthermore, AKTIP may also play a role in autophagy, a cellular process involved in the degradation and recycling of cellular components.

Protein Structure:

• N-Terminal Domain: Contains regions that mediate interactions with other proteins, including members of the AKT family.
• C-Terminal Domain: Involved in DNA repair processes and contains motifs crucial for the nuclear localization of the protein.
• Phosphorylation Sites: AKTIP is subject to post-translational modifications, including phosphorylation, which can regulate its activity and interactions.

Classification and Subtypes:

• Family: AKTIP belongs to the family of proteins involved in signal transduction pathways.
• Subtypes: AKTIP does not have well-defined subtypes but is part of the broader category of proteins that interact with AKT kinases.

Function and Biological Significance:

• AKT Interaction: AKTIP modulates the activity of AKT kinases, influencing pathways that control cell survival and proliferation.
• DNA Repair: AKTIP is involved in the DNA repair process, particularly in the response to DNA damage, which is crucial for maintaining genomic stability.
• Cell Cycle Regulation: By interacting with AKT and other proteins, AKTIP plays a role in regulating the cell cycle and ensuring proper cell division.
• Apoptosis: AKTIP can influence apoptotic pathways, either promoting or inhibiting cell death depending on the context and interactions with other signaling molecules.

Interactions:

• AKT Kinases: AKTIP directly interacts with AKT1, AKT2, and AKT3, modulating their activity and downstream signaling pathways.
• DNA Repair Proteins: AKTIP interacts with proteins involved in the DNA damage response, facilitating repair processes.
• Cell Cycle Regulators: It also interacts with proteins that regulate the cell cycle, ensuring proper progression through different phases.

Clinical Issues:

• Cancer: Dysregulation of AKTIP can contribute to tumorigenesis. Its role in DNA repair and cell cycle regulation makes it a potential factor in cancer development and progression.
• Genetic Disorders: Mutations in the AKTIP gene or its dysregulation can lead to genomic instability, contributing to various genetic disorders.
• Therapeutic Target: Given its interaction with AKT kinases and involvement in critical cellular processes, AKTIP is being studied as a potential therapeutic target for diseases such as cancer.

Summary:

AKTIP is a multifunctional protein that interacts with AKT kinases and plays vital roles in cell survival, proliferation, DNA repair, and apoptosis. Its involvement in these essential cellular processes makes it a critical factor in maintaining cellular homeostasis. Dysregulation of AKTIP can lead to cancer and other genetic disorders, highlighting its importance as a potential therapeutic target. Understanding the molecular mechanisms of AKTIP's interactions and functions can provide insights into its role in health and disease.