AKT Interacting Protein (AKTIP) Antibody

Pida mas información
935106861
info@markelab.com
Precio
195€ (20 µl)
Antibody anti-AKTIP
proveedor
Abbexareference
abx004764Tested Applications
ELISA, WB, IHCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
AKTIP Antibody is a Rabbit Polyclonal antibody against AKTIP. The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
Background
AKT Interacting Protein (AKTIP) is a multifunctional protein that plays a role in the regulation of cellular proliferation, survival, and DNA repair by interacting with AKT, a serine/threonine kinase involved in key signaling pathways. AKTIP is implicated in the maintenance of telomere integrity and genomic stability by facilitating telomere replication and protecting telomeres from damage. It also functions in vesicular trafficking and lipid metabolism, linking it to processes such as endosome dynamics and cellular energy homeostasis. Dysregulation of AKTIP is associated with genomic instability, which can lead to cancer progression and age-related diseases. AKTIP is also being studied for its role in insulin signaling and metabolic disorders due to its interaction with the AKT pathway. Research into AKTIP continues to uncover its broader implications in cellular signaling and its potential as a therapeutic target in cancer and metabolic dysfunction.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
AKT Interacting Protein (AKTIP)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
size 1
20 µl
size 2
100 µl
size 3
2 × 100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
AKTIP
dry ice
No
availability
Shipped within 5-10 working days.
alias
AKTIP,FTS
uniprot id
NCBI accession
NP_071921.1
note
Concentration: > 0.2 mg/ml -
Quizá le pueda interesar
anti- AKTIP antibody

proveedor
FineTestreference
FNab00274Tested Applications
ELISA, WB, IHCreactivity
human,mouse,ratstatus
RUOclonality
polyclonalThe mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygou...
Precio a consultar
Ver másAKT Interacting Protein (AKTIP) Antibody

proveedor
Abbexareference
abx004764Tested Applications
ELISA, WB, IHCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalAKTIP Antibody is a Rabbit Polyclonal antibody against AKTIP. The mouse homolog of this gene produces fused toes and thy...
195€ (20 µl)
Ver másAKT Interacting Protein (AKTIP) Antibody

proveedor
Abbexareference
abx030975Tested Applications
ELISA, WBreactivity
Humanstatus
RUOclonality
PolyclonalThe mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygou...
292.5€ (80 µl)
Ver más