AKT Interacting Protein (AKTIP) Antibody

Este producto es parte de AKTIP - AKT Interacting Protein
AKT Interacting Protein (AKTIP) Antibody

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935106861

info@markelab.com

Precio

195€ (20 µl)

Antibody anti-AKTIP

proveedor

Abbexa

reference

abx004764

Tested Applications

ELISA, WB, IHC

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

AKTIP Antibody is a Rabbit Polyclonal antibody against AKTIP. The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.


Background

AKT Interacting Protein (AKTIP) is a multifunctional protein that plays a role in the regulation of cellular proliferation, survival, and DNA repair by interacting with AKT, a serine/threonine kinase involved in key signaling pathways. AKTIP is implicated in the maintenance of telomere integrity and genomic stability by facilitating telomere replication and protecting telomeres from damage. It also functions in vesicular trafficking and lipid metabolism, linking it to processes such as endosome dynamics and cellular energy homeostasis. Dysregulation of AKTIP is associated with genomic instability, which can lead to cancer progression and age-related diseases. AKTIP is also being studied for its role in insulin signaling and metabolic disorders due to its interaction with the AKT pathway. Research into AKTIP continues to uncover its broader implications in cellular signaling and its potential as a therapeutic target in cancer and metabolic dysfunction.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Mouse, Rat


immunogen target

AKT Interacting Protein (AKTIP)


host

Rabbit


isotype

IgG


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB, IHC


purification

Purified by affinity chromatography.


recommended dilution

ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.


buffer

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.


size 1

20 µl


size 2

100 µl


size 3

2 × 100 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

AKTIP


dry ice

No


availability

Shipped within 5-10 working days.


alias

AKTIP,FTS


NCBI accession

NP_071921.1


note

Concentration: > 0.2 mg/ml -


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ELISA, WB, IHC

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status

RUO

clonality

Polyclonal

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