A-Kinase Anchor Protein 8 (AKAP8) Cell ELISA Kit
513.5€ (96 tests)
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935106861
info@markelab.com
name
A-Kinase Anchor Protein 8 (AKAP8) Cell ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx595665
tested applications
ELISA
Description
A-Kinase Anchor Protein 8 (AKAP8) Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | A-Kinase Anchor Protein 8 (AKAP8) |
| Reactivity | Human, Mouse, Rat |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. The validity for this kit is at least 6 months |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O43823 |
| Gene ID | 10270 |
| OMIM | 604692 |
| Alias | AKAP8, AKAP95 |
| Background | Elisa kits for AKAP8 |
| Status | RUO |
| Note | Validity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AKAP8, also known as AKAP95, is a nuclear scaffold protein that anchors PKA and other enzymes to chromatin and nuclear compartments, playing key roles in RNA processing, mitotic progression, and chromatin remodeling. AKAP8 regulates PKA-dependent phosphorylation of nuclear substrates involved in RNA splicing and transcriptional regulation, ensuring efficient gene expression during cell cycle progression. It also participates in mitotic events by anchoring protein phosphatase 1 (PP1) and chromatin-associated proteins to organize chromosome condensation and segregation. AKAP8 interacts with histones and chromatin remodelers, linking it to epigenetic regulation during cell differentiation and stress responses. Dysregulation of AKAP8 has been associated with aberrant gene expression, chromosomal instability, and cancer progression. In addition, AKAP8 plays a role in viral replication, where it acts as a scaffold for proteins involved in nuclear viral RNA export. Its localization and function make it a crucial regulator of nuclear processes.
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