A-Kinase Anchor Protein 8 (AKAP8) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
A-Kinase Anchor Protein 8 (AKAP8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx007337
tested applications
IF/ICC
Description
AKAP8 Antibody is a Rabbit Polyclonal Antibody against AKAP8.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A-Kinase Anchor Protein 8 (AKAP8) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43823 |
| Gene ID | 10270 |
| NCBI Accession | NP_005849.1 |
| Alias | AKAP8, AKAP95 |
| Background | Antibody anti-AKAP8 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
AKAP8, also known as AKAP95, is a nuclear scaffold protein that anchors PKA and other enzymes to chromatin and nuclear compartments, playing key roles in RNA processing, mitotic progression, and chromatin remodeling. AKAP8 regulates PKA-dependent phosphorylation of nuclear substrates involved in RNA splicing and transcriptional regulation, ensuring efficient gene expression during cell cycle progression. It also participates in mitotic events by anchoring protein phosphatase 1 (PP1) and chromatin-associated proteins to organize chromosome condensation and segregation. AKAP8 interacts with histones and chromatin remodelers, linking it to epigenetic regulation during cell differentiation and stress responses. Dysregulation of AKAP8 has been associated with aberrant gene expression, chromosomal instability, and cancer progression. In addition, AKAP8 plays a role in viral replication, where it acts as a scaffold for proteins involved in nuclear viral RNA export. Its localization and function make it a crucial regulator of nuclear processes.
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