Agouti Related Protein (AGRP) Antibody

Este producto es parte de AGRP - Agouti Related Neuropeptide
Product Graph
780€ (1 ml)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Agouti Related Protein (AGRP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx171130
tested applications
WB, IHC, IF/ICC

Description

This product is currently in development. The lead time for this product may be several months. Please contact us at

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Agouti Related Protein (AGRP)
Host
Mouse
Reactivity
Human
Recommended Dilution
WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Purification
Purified by Protein A and Protein G affinity chromatography.
Size 1
1 ml
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability
Please enquire.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
AGRT,ART,ASIP2
Background
Antibody anti-AGRP
Status
RUO

Descripción

Agouti-related neuropeptide (AGRP) is a peptide hormone primarily produced in the arcuate nucleus of the hypothalamus in the brain. AGRP plays a crucial role in regulating appetite and energy balance by acting as an antagonist to the melanocortin receptors, particularly the melanocortin-4 receptor (MC4R). By inhibiting MC4R activity, AGRP increases appetite and promotes feeding behavior, leading to weight gain and adiposity. Dysregulation of AGRP signaling has been in obesity and metabolic disorders. Additionally, AGRP neurons are sensitive to nutritional cues and hormonal signals, allowing them to integrate various inputs to modulate feeding behavior accordingly. Pharmacological targeting of AGRP signaling holds promise for the treatment of obesity and related metabolic conditions. Research into the molecular mechanisms underlying AGRP function provides insights into appetite regulation and potential therapeutic avenues for obesity management. Ongoing studies continue to elucidate the complex roles of AGRP in energy homeostasis and metabolic health.

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