Agouti Related Protein (AGRP) Antibody
195€ (20 µl)
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935106861
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name
Agouti Related Protein (AGRP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx005673
tested applications
ELISA, WB, IHC
Description
AGRP Antibody is a Rabbit Polyclonal Antibody against AGRP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Agouti Related Protein (AGRP) |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00253 |
| Gene ID | 181 |
| NCBI Accession | NP_001129.1 |
| Alias | AGRT,ART,ASIP2 |
| Background | Antibody anti-AGRP |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
Agouti-related neuropeptide (AGRP) is a peptide hormone primarily produced in the arcuate nucleus of the hypothalamus in the brain. AGRP plays a crucial role in regulating appetite and energy balance by acting as an antagonist to the melanocortin receptors, particularly the melanocortin-4 receptor (MC4R). By inhibiting MC4R activity, AGRP increases appetite and promotes feeding behavior, leading to weight gain and adiposity. Dysregulation of AGRP signaling has been in obesity and metabolic disorders. Additionally, AGRP neurons are sensitive to nutritional cues and hormonal signals, allowing them to integrate various inputs to modulate feeding behavior accordingly. Pharmacological targeting of AGRP signaling holds promise for the treatment of obesity and related metabolic conditions. Research into the molecular mechanisms underlying AGRP function provides insights into appetite regulation and potential therapeutic avenues for obesity management. Ongoing studies continue to elucidate the complex roles of AGRP in energy homeostasis and metabolic health.
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