Adhesion Molecule With Ig Like Domain 3 (AMIGO3) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Adhesion Molecule With Ig Like Domain 3 (AMIGO3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230361
tested applications
ELISA, WB
Description
AMIGO3 Antibody is a Rabbit Polyclonal against AMIGO3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adhesion Molecule With Ig Like Domain 3 (AMIGO3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q86WK7 |
| Gene ID | 386724 |
| OMIM | 615691 |
| Alias | AMIGO3,ALI3,Alivin-3 |
| Background | Antibody anti-AMIGO3 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
AMIGO3 is a member of the AMIGO family that primarily functions in cell adhesion, neuronal development, and cell survival signaling. It is expressed in the central nervous system, where it regulates axon guidance and myelination during neural development. AMIGO3 interacts with other adhesion molecules and extracellular ligands to modulate axon extension and fasciculation, contributing to the formation of functional neural networks. Beyond its role in neural development, AMIGO3 has been implicated in promoting neuronal apoptosis in response to injury or stress, particularly in neuroinflammatory and neurodegenerative conditions. It has also been linked to tumor progression, where it enhances cancer cell survival, migration, and invasion. AMIGO3 is involved in activating signaling pathways such as NF-κB and PI3K/AKT, which support cell survival and inflammatory responses. Its involvement in both neural apoptosis and cancer progression highlights AMIGO3 as a critical player in cellular signaling pathways related to survival and disease.
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