Adhesion Molecule With Ig Like Domain 1 (AMIGO1) Antibody (FITC)
169€ (20 µg)
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name
Adhesion Molecule With Ig Like Domain 1 (AMIGO1) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx308341
Description
AMIGO1 Antibody (FITC) is a Rabbit Polyclonal against AMIGO1 conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adhesion Molecule With Ig Like Domain 1 (AMIGO1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q86WK6 |
| Gene ID | 57463 |
| OMIM | 615689 |
| Alias | AMIGO-1,Alivin-2 |
| Background | Antibody anti-AMIGO1 |
| Status | RUO |
Descripción
AMIGO1 is a cell adhesion molecule belonging to the AMIGO family, which is involved in neuronal development, axon guidance, and synaptic formation. AMIGO1 is highly expressed in the central nervous system (CNS), where it mediates neurite outgrowth and contributes to axon fasciculation during neural circuit formation. It interacts with other cell adhesion molecules and extracellular matrix proteins to promote cell-cell and cell-extracellular interactions critical for proper neuronal connectivity. AMIGO1 has also been implicated in synaptic plasticity and stability, supporting learning, memory, and neural repair. Dysregulation of AMIGO1 has been associated with neurodegenerative diseases such as Alzheimer’s disease, where axonal damage and synaptic dysfunction are observed. In addition to its neuronal roles, emerging evidence suggests that AMIGO1 may influence tumor progression, as its expression can promote cell migration and invasion in certain cancers. This highlights its dual significance in both neural development and disease pathology.
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