Adenylate Kinase 7 (AK7) Antibody

Background

AK7 is a cytosolic and cytoskeletal-associated isoform uniquely involved in energy homeostasis and the regulation of ciliary function. AK7 is expressed predominantly in ciliated tissues, such as the respiratory epithelium, reproductive tract, and central nervous system. It has been identified as a crucial protein for cilia stabilization and energy supply, where it maintains ATP levels necessary for ciliary beating and motility. Mutations in AK7 are linked to primary ciliary dyskinesia (PCD), a condition characterized by impaired cilia function leading to chronic respiratory infections, reduced mucociliary clearance, and male infertility. AK7 has also been implicated in neurodegenerative processes, as defects in energy metabolism can disrupt cellular homeostasis in neurons. Beyond ciliary function, AK7 is associated with cellular stress responses, where it regulates energy distribution during high-energy demands. Its involvement in maintaining cytoskeletal integrity and supporting ATP synthesis highlights its broader role in cellular motility and division, particularly in tissues with high turnover or mechanical activity.