Adenylate Kinase 7 (AK7) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
The adenylate kinases (AK) are a family of structurally and functionally related enzymes that catalyze a similar reaction, MgNTP + AMP = MgNDP + ADP (N = A or G). The AK enzymes are important for maintenance of homeostasis of the adenine and guanine nucleotide pools. AK1 is a cytosolic enzyme for which ATP is the substrate. AK2 catalyzes the same reaction as AK1, but it is localized in the mitochondrial intermembrane space. AK3 is present in the mitochondrial matrix and prefers GTP over ATP as the substrate.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adenylate Kinase 7 (AK7) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96M32 |
| Alias | CFAP75,FAP75,SPGF27 |
| Background | Antibody anti-AK7 |
| Status | RUO |
Descripción
AK7 is a cytosolic and cytoskeletal-associated isoform uniquely involved in energy homeostasis and the regulation of ciliary function. AK7 is expressed predominantly in ciliated tissues, such as the respiratory epithelium, reproductive tract, and central nervous system. It has been identified as a crucial protein for cilia stabilization and energy supply, where it maintains ATP levels necessary for ciliary beating and motility. Mutations in AK7 are linked to primary ciliary dyskinesia (PCD), a condition characterized by impaired cilia function leading to chronic respiratory infections, reduced mucociliary clearance, and male infertility. AK7 has also been implicated in neurodegenerative processes, as defects in energy metabolism can disrupt cellular homeostasis in neurons. Beyond ciliary function, AK7 is associated with cellular stress responses, where it regulates energy distribution during high-energy demands. Its involvement in maintaining cytoskeletal integrity and supporting ATP synthesis highlights its broader role in cellular motility and division, particularly in tissues with high turnover or mechanical activity.
Related Products
Adenylate Kinase 7 (AK7) Antibody
The adenylate kinases (AK) are a family of structurally and functionally related enzymes that catalyze a similar reaction, MgNTP + AMP = MgNDP + ADP (N = A or G). The AK enzymes are important for maintenance of homeostasis of the adenine and guanine nucleotide pools. AK1 is a cytosolic enzyme for which ATP is the substrate. AK2 catalyzes the same reaction as AK1, but it is localized in the mitochondrial intermembrane space. AK3 is present in the mitochondrial matrix and prefers GTP over ATP as the substrate.
Ver Producto
Human Adenylate kinase 7 (AK7) ELISA Kit
Human Adenylate kinase 7 (AK7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Adenylate kinase 7 (AK7) concentrations in tissue homogenates, cell lysates and other biological fluids.
Ver ProductoMouse Adenylate kinase 7 (AK7) ELISA Kit
Mouse Adenylate kinase 7 (AK7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Adenylate kinase 7 concentrations in tissue homogenates, cell lysates and other biological fluids.
Ver Producto