Adenylate Kinase 4, Mitochondrial (AK4) Antibody
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935106861
info@markelab.com
Precio
195€ (20 µl)
Antibody anti-AK4
proveedor
Abbexareference
abx001667Tested Applications
ELISA, WB, IF/ICC, IPreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
AK4 Antibody is a Rabbit Polyclonal antibody against AK4. This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008].
Background
AK4, also localized in the mitochondrial matrix, is a catalytically inactive adenylate kinase homolog involved in stress response and ATP metabolism regulation. Despite lacking enzymatic activity, AK4 interacts with other AK isoforms to regulate energy homeostasis under stress conditions, including hypoxia or metabolic reprogramming. AK4 expression is elevated in some cancers, suggesting a role in tumor progression and survival. It functions in modulating mitochondrial dynamics and improving resistance to oxidative stress, particularly in high-metabolic tissues like the heart. AK4 has also been linked to cellular signaling pathways regulating apoptosis, energy metabolism, and DNA repair.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Adenylate Kinase 4, Mitochondrial (AK4)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IF/ICC, IP
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200, IP: 0.5 µg - 4 µg antibody per 200 µg - 400 µg extracts of whole cells. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
size 1
20 µl
size 2
100 µl
size 3
2 × 100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
AK4
dry ice
No
availability
Shipped within 5-10 working days.
alias
AK4,AK3,AK3L1,AK3L2
uniprot id
NCBI accession
NP_037542.1
note
Concentration: 1.19 mg/ml -
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Abbexareference
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ELISA, WB, IF/ICC, IPreactivity
Human, Mouse, Ratstatus
RUOclonality
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