Adenylate Kinase 4, Mitochondrial (AK3L1) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
AK3L1 Antibody is a Rabbit Polyclonal against AK3L1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adenylate Kinase 4, Mitochondrial (AK3L1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P27144 |
| Alias | AK4,AK3,AK3L1,AK3L2 |
| Background | Antibody anti-AK4 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
AK4, also localized in the mitochondrial matrix, is a catalytically inactive adenylate kinase homolog involved in stress response and ATP metabolism regulation. Despite lacking enzymatic activity, AK4 interacts with other AK isoforms to regulate energy homeostasis under stress conditions, including hypoxia or metabolic reprogramming. AK4 expression is elevated in some cancers, suggesting a role in tumor progression and survival. It functions in modulating mitochondrial dynamics and improving resistance to oxidative stress, particularly in high-metabolic tissues like the heart. AK4 has also been linked to cellular signaling pathways regulating apoptosis, energy metabolism, and DNA repair.
Related Products
AK4 antibody
This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1.
Ver Producto
Recombinant Human AK4
Ver Producto
Adenylate Kinase 4, Mitochondrial (AK4) Antibody
AK4 Antibody is a Rabbit Polyclonal antibody against AK4. This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008].
Ver Producto