Adenylate Kinase 4, Mitochondrial (AK3L1) Antibody
357.5€ (100 µg)
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Name
Adenylate Kinase 4, Mitochondrial (AK3L1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx037024
Tested Applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the AK3L1 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Adenylate Kinase 4, Mitochondrial (AK3L1) Immunogen: Recombinant fragment corresponding to 38-222 AA of human AK3L1. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 30 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AK4,AK3,AK3L1,AK3L2 |
| Background | Antibody anti-AK4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AK4, also localized in the mitochondrial matrix, is a catalytically inactive adenylate kinase homolog involved in stress response and ATP metabolism regulation. Despite lacking enzymatic activity, AK4 interacts with other AK isoforms to regulate energy homeostasis under stress conditions, including hypoxia or metabolic reprogramming. AK4 expression is elevated in some cancers, suggesting a role in tumor progression and survival. It functions in modulating mitochondrial dynamics and improving resistance to oxidative stress, particularly in high-metabolic tissues like the heart. AK4 has also been linked to cellular signaling pathways regulating apoptosis, energy metabolism, and DNA repair.
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