Adenylate Kinase 3 (AK3) Antibody
819€ (1 ml)
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Name
Adenylate Kinase 3 (AK3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx171091
Tested Applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Adenylate Kinase 3 (AK3) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AK3L1,AK6,AKL3L |
| Background | Antibody anti-AK3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AK3 is localized within the mitochondrial matrix and utilizes GTP as a phosphate donor instead of ATP, distinguishing it from other AK isoforms. AK3 primarily supports mitochondrial nucleotide exchange, particularly during periods of cellular energy stress. It is abundant in tissues with high-energy demands, such as the brain, liver, and kidneys. AK3 contributes to mitochondrial respiration by facilitating ADP recycling necessary for oxidative phosphorylation. Knockout studies demonstrate that AK3 deficiency disrupts ATP synthesis and exacerbates oxidative stress, which can contribute to neurodegenerative conditions. AK3 has also been implicated in regulating mitochondrial dynamics and maintaining redox balance.
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