Adenylate Cyclase Type 5/6 (ADCY5/6) Antibody
52€ (10 µg)
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Name
Adenylate Cyclase Type 5/6 (ADCY5/6) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx013897
Tested Applications
ELISA, IHC, IF/ICC
Description
Rabbit polyclonal antibody against ADCY5/6 protein. Immunogen region is C-terminal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Adenylate Cyclase Type 5/6 (ADCY5/6) Immunogen: The antiserum was produced against synthesized peptide derived from C-terminal of human ADCY5/6. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/500, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43306, O95622 |
| Alias | AC5, DSKOD, FDFM |
| Background | Antibody anti-ADCY5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ADCY5 is a G-protein-regulated, membrane-bound enzyme highly expressed in the heart and brain. It is critical for cardiac function, including regulating heart rate and contractility through cAMP production. In the brain, ADCY5 mediates dopamine signaling and contributes to motor control. Mutations in ADCY5 have been linked to familial dyskinesia and neurological movement disorders. It is also implicated in cardiac pathologies, such as heart failure, due to its central role in cAMP-dependent signaling in cardiomyocytes.
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