Adenylate Cyclase 1, Brain (ADCY1) Antibody

Product specifications

Primary Antibodies

Adenylate Cyclase 1, Brain (ADCY1)

Rabbit

Human

WB: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

≥ 95% (SDS-PAGE)

Purified by immunogen affinity chromatography.

100 µg

Liquid

ELISA, WB

PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.

Shipped within 5-12 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

Q08828

107

AC1,DFNB44,ATP pyrophosphate-lyase 1

Antibody anti-ADCY1

RUO

Concentration: 2 mg/ml - Validity: 12 months.

Descripción

ADCY1 is a membrane-bound enzyme predominantly expressed in the brain, specifically in neuronal tissues. It is activated by G-protein-coupled receptors (GPCRs) and regulated by calcium/calmodulin, playing a vital role in generating cyclic AMP (cAMP), a second messenger critical for signal transduction. ADCY1 is essential for synaptic plasticity, learning, and memory processes. Dysregulation of ADCY1 has been linked to neurological disorders, such as cognitive impairments and epilepsy, due to impaired cAMP signaling pathways. Its expression and activity are crucial for calcium-dependent cAMP production in neurons.

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