Adenosylhomocysteinase Like 1 (AHCYL1) Antibody
169€ (20 µl)
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Name
Adenosylhomocysteinase Like 1 (AHCYL1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx321651
Tested Applications
ELISA, WB, IHC
Description
AHCYL1 Antibody is a Rabbit Polyclonal against AHCYL1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Adenosylhomocysteinase Like 1 (AHCYL1) Immunogen: Recombinant human Adenosylhomocysteinase 2 protein (31-260AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43865 |
| Gene ID | 10768 |
| NCBI Accession | NM_006621.5 |
| OMIM | 607826 |
| Alias | DCAL,IRBIT,PPP1R78 |
| Background | Antibody anti-AHCYL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AHCYL1, also known as inositol 1,4,5-triphosphate receptor binding protein (IRBIT), is structurally similar to AHCY but lacks catalytic activity. Instead, it functions as a regulator of calcium signaling and ion transport. AHCYL1 binds to inositol 1,4,5-triphosphate receptors (IP3Rs), modulating calcium release from the endoplasmic reticulum (ER), and interacts with transporters such as the sodium-bicarbonate cotransporter (NBCe1) to regulate intracellular pH and bicarbonate levels. It is expressed in various tissues, including the kidneys, brain, and pancreas, where it influences processes such as fluid secretion, neuronal excitability, and electrolyte balance. Dysregulation of AHCYL1 has been linked to diseases such as kidney disorders, neurodegenerative diseases, and cystic fibrosis, highlighting its importance in calcium and ion homeostasis.
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