Adenosylhomocysteinase Like 1 (AHCYL1) Antibody
195€ (20 µl)
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935106861
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name
Adenosylhomocysteinase Like 1 (AHCYL1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx006676
tested applications
ELISA, WB
Description
AHCYL1 Antibody is a Rabbit Polyclonal Antibody against AHCYL1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adenosylhomocysteinase Like 1 (AHCYL1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43865 |
| Gene ID | 10768 |
| NCBI Accession | NP_006612.2 |
| Alias | DCAL,IRBIT,PPP1R78 |
| Background | Antibody anti-AHCYL1 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
AHCYL1, also known as inositol 1,4,5-triphosphate receptor binding protein (IRBIT), is structurally similar to AHCY but lacks catalytic activity. Instead, it functions as a regulator of calcium signaling and ion transport. AHCYL1 binds to inositol 1,4,5-triphosphate receptors (IP3Rs), modulating calcium release from the endoplasmic reticulum (ER), and interacts with transporters such as the sodium-bicarbonate cotransporter (NBCe1) to regulate intracellular pH and bicarbonate levels. It is expressed in various tissues, including the kidneys, brain, and pancreas, where it influences processes such as fluid secretion, neuronal excitability, and electrolyte balance. Dysregulation of AHCYL1 has been linked to diseases such as kidney disorders, neurodegenerative diseases, and cystic fibrosis, highlighting its importance in calcium and ion homeostasis.
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