Adenosylhomocysteinase Like 1 (AHCYL1) Antibody
357.5€ (100 µg)
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935106861
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name
Adenosylhomocysteinase Like 1 (AHCYL1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037861
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the AHCYL1 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adenosylhomocysteinase Like 1 (AHCYL1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_006621 |
| Alias | DCAL,IRBIT,PPP1R78 |
| Background | Antibody anti-AHCYL1 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
AHCYL1, also known as inositol 1,4,5-triphosphate receptor binding protein (IRBIT), is structurally similar to AHCY but lacks catalytic activity. Instead, it functions as a regulator of calcium signaling and ion transport. AHCYL1 binds to inositol 1,4,5-triphosphate receptors (IP3Rs), modulating calcium release from the endoplasmic reticulum (ER), and interacts with transporters such as the sodium-bicarbonate cotransporter (NBCe1) to regulate intracellular pH and bicarbonate levels. It is expressed in various tissues, including the kidneys, brain, and pancreas, where it influences processes such as fluid secretion, neuronal excitability, and electrolyte balance. Dysregulation of AHCYL1 has been linked to diseases such as kidney disorders, neurodegenerative diseases, and cystic fibrosis, highlighting its importance in calcium and ion homeostasis.
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