Adenosine Deaminase Domain-Containing Protein 1 (ADAD1) Antibody
169€ (20 µl)
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935106861
info@markelab.com
name
Adenosine Deaminase Domain-Containing Protein 1 (ADAD1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx320697
tested applications
ELISA, IHC
Description
ADAD1 Antibody is a Rabbit Polyclonal against ADAD1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adenosine Deaminase Domain-Containing Protein 1 (ADAD1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96M93 |
| Gene ID | 132612 |
| NCBI Accession | NP_001152757.1, NM_001159285.1, NP_001152767.1, NM_001159295.1, NP_640336.1, NM_139243.3 |
| OMIM | 614130 |
| Alias | Testis nuclear RNA-binding protein,TENR |
| Background | Antibody anti-ADAD1 |
| Status | RUO |
Descripción
ADAD1 is a member of the adenosine deaminase domain-containing family, primarily expressed in the testis, where it plays a significant role in RNA metabolism, particularly in the regulation of RNA stability and processing during spermatogenesis. This protein is thought to bind double-stranded RNA, influencing the stability and translation of specific mRNA transcripts critical for germ cell development. Its expression is tightly regulated, reflecting its importance in meiotic progression and gametogenesis. Although ADAD1 shares a conserved adenosine deaminase domain, its enzymatic activity toward adenosine is not well characterized, suggesting its role may primarily be structural or regulatory in RNA binding rather than catalytic. Dysregulation or mutations in ADAD1 have been implicated in male infertility due to disrupted spermatogenic processes. Its testis-specific expression underscores its specialized function in reproductive biology.
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