Adenosine Deaminase Domain-Containing Protein 1 (ADAD1) Antibody
357.5€ (100 µg)
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Name
Adenosine Deaminase Domain-Containing Protein 1 (ADAD1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx038076
Tested Applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ADAD1 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Adenosine Deaminase Domain-Containing Protein 1 (ADAD1) Immunogen: Recombinant fragment corresponding to 72-323 AA of human ADAD1. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 64 kDa |
| Purification | Purified by Protein A/G column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Testis nuclear RNA-binding protein,TENR |
| Background | Antibody anti-ADAD1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ADAD1 is a member of the adenosine deaminase domain-containing family, primarily expressed in the testis, where it plays a significant role in RNA metabolism, particularly in the regulation of RNA stability and processing during spermatogenesis. This protein is thought to bind double-stranded RNA, influencing the stability and translation of specific mRNA transcripts critical for germ cell development. Its expression is tightly regulated, reflecting its importance in meiotic progression and gametogenesis. Although ADAD1 shares a conserved adenosine deaminase domain, its enzymatic activity toward adenosine is not well characterized, suggesting its role may primarily be structural or regulatory in RNA binding rather than catalytic. Dysregulation or mutations in ADAD1 have been implicated in male infertility due to disrupted spermatogenic processes. Its testis-specific expression underscores its specialized function in reproductive biology.
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