ADAM Metallopeptidase With Thrombospondin Type 1 Motif 6 (ADAMTS6) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 6 (ADAMTS6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx339725
tested applications
ELISA, IHC
Description
ADAMTS6 Antibody is a Rabbit Polyclonal against ADAMTS6.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 6 (ADAMTS6) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/1000 - 1/5000, IHC: 1/15 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UKP5 |
| Gene ID | 11174 |
| Alias | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 6,ADAM-TS 6,ADAMTS-6 |
| Background | Antibody anti-ADAMTS6 |
| Status | RUO |
Descripción
ADAMTS6 ,A Disintegrin And Metalloproteinase with Thrombospondin Motifs 6 is a member of the ADAMTS (ADAM with thrombospondin motifs) family of proteases. ADAMTS6 belongs to a group of multidomain proteases characterized by the presence of a metalloproteinase domain, a disintegrin-like domain, and various thrombospondin type-1 (TSP-1) motifs. ADAMTS6 is expressed in various tissues, including skeletal muscle, heart, brain, kidney, and lung. Its expression pattern suggests potential roles in tissue development and homeostasis.ADAMTS6 has been implicated in several physiological and pathological processes. Studies suggest its involvement in ECM remodeling, particularly in the degradation and processing of proteoglycans and other ECM components. It may also play roles in angiogenesis, wound healing, and inflammation.Dysregulation of ADAMTS6 has been implicated in various diseases. For example, altered expression of ADAMTS6 has been reported in cancers, such as breast cancer, where it may influence tumor progression and metastasis. Additionally, mutations in the ADAMTS6 gene have been linked to certain genetic disorders and developmental abnormalities.
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