ADAMTS6 - ADAM metallopeptidase with thrombospondin type 1 motif 6 | Elisa - Clia - Antibody - Protein

Background

ADAMTS6 ,A Disintegrin And Metalloproteinase with Thrombospondin Motifs 6 is a member of the ADAMTS (ADAM with thrombospondin motifs) family of proteases. ADAMTS6 belongs to a group of multidomain proteases characterized by the presence of a metalloproteinase domain, a disintegrin-like domain, and various thrombospondin type-1 (TSP-1) motifs. ADAMTS6 is expressed in various tissues, including skeletal muscle, heart, brain, kidney, and lung. Its expression pattern suggests potential roles in tissue development and homeostasis.ADAMTS6 has been implicated in several physiological and pathological processes. Studies suggest its involvement in ECM remodeling, particularly in the degradation and processing of proteoglycans and other ECM components. It may also play roles in angiogenesis, wound healing, and inflammation.Dysregulation of ADAMTS6 has been implicated in various diseases. For example, altered expression of ADAMTS6 has been reported in cancers, such as breast cancer, where it may influence tumor progression and metastasis. Additionally, mutations in the ADAMTS6 gene have been linked to certain genetic disorders and developmental abnormalities.

Protein Structure

ADAMTS6 shares a typical structure found in the ADAMTS family, which includes several functional domains:

• Signal Peptide: Guides the enzyme to the secretory pathway.
• Propeptide Domain: Keeps the enzyme inactive until it is cleaved to activate the enzyme.
• Metalloprotease Domain: Contains the catalytic site with a zinc-binding motif essential for its proteolytic activity.
• Disintegrin-Like Domain: Facilitates interactions with integrins and other cell surface receptors.
• Thrombospondin Type 1 Repeats (TSP1): ADAMTS6 contains multiple TSP1 motifs involved in binding to ECM components and other proteins, aiding in cell adhesion and signaling.
• Cysteine-Rich Domain: Contributes to the enzyme’s stability and interactions.
• Spacer Domain: Connects other domains and influences substrate specificity and binding.

Classification and Subtypes

ADAMTS6 is classified within the ADAMTS family, a group characterized by the presence of TSP1 motifs and metalloprotease domains. While ADAMTS6 does not have distinct subtypes, it shares functional and structural characteristics with other ADAMTS enzymes involved in ECM remodeling and developmental processes.

Function and Biological Significance

ADAMTS6 is involved in several key biological processes:

1. Extracellular Matrix Remodeling: Cleaves ECM components, contributing to tissue remodeling and maintenance.
2. Developmental Processes: Plays roles in tissue morphogenesis and organ development, although specific substrates and pathways are still under investigation.
3. Tissue Repair and Homeostasis: Participates in the normal turnover and repair of tissues by regulating ECM dynamics.

Interactions

ADAMTS6 interacts with several proteins and cellular components:

1. Extracellular Matrix Proteins: Likely interacts with and cleaves various ECM components, participating in ECM turnover and remodeling.
2. Integrins: The disintegrin-like domain may facilitate interactions with integrins, affecting cell adhesion, signaling, and migration.
3. Thrombospondins: The TSP1 motifs mediate interactions with thrombospondins and other ECM proteins, playing a role in cell-matrix communication.
4. Growth Factors and Cytokines: May modulate the activity of various growth factors and cytokines, influencing cellular behavior and tissue responses.

Clinical Significance

ADAMTS6 has potential clinical implications in various contexts:

1. Developmental Disorders: Given its role in developmental processes, mutations or dysregulation of ADAMTS6 could contribute to developmental abnormalities, although specific conditions have yet to be fully characterized.
2. Fibrosis: As an ECM-modulating enzyme, ADAMTS6 might be involved in fibrotic diseases where excessive ECM deposition occurs.
3. Cancer: Altered expression of ADAMTS6 has been observed in certain cancers, suggesting a potential role in tumor progression and metastasis, although further research is needed to clarify its function in cancer biology.

Summary

ADAMTS6 is an important enzyme in the ADAMTS family, primarily involved in ECM remodeling and developmental processes. Its multi-domain structure, including the metalloprotease and TSP1 domains, enables it to interact with various ECM components and cellular receptors. ADAMTS6 plays crucial roles in maintaining tissue integrity and is implicated in development, fibrosis, and potentially cancer. Understanding its structure, functions, interactions, and clinical implications provides valuable insights into its roles in various physiological and pathological processes.