Acyl-Coenzyme A Thioesterase 4 (ACOT4) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Acyl-Coenzyme A Thioesterase 4 (ACOT4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx014150
tested applications
ELISA, WB, IF/ICC
Description
Rabbit polyclonal antibody against ACOT4 protein. Immunogen region is C-terminal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acyl-Coenzyme A Thioesterase 4 (ACOT4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/3000, IF/ICC: 1/100 - 1/500, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8N9L9 |
| Alias | PTE1B,PTE2B,PTE-Ib |
| Background | Antibody anti-ACOT4 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ACOT4 is a peroxisomal enzyme that hydrolyzes medium- and long-chain acyl-CoA esters into free fatty acids and CoA, contributing to the regulation of peroxisomal β-oxidation and lipid metabolism. It is expressed in tissues involved in lipid processing, such as the liver and kidney, where it participates in detoxifying acyl-CoA intermediates and modulating lipid signaling pathways. ACOT4 plays a key role in the breakdown of branched-chain fatty acids and bile acid intermediates, processes essential for maintaining cellular lipid homeostasis. By regulating the levels of peroxisomal CoA and free fatty acids, ACOT4 influences cellular metabolic efficiency and prevents lipid toxicity. Dysregulation of ACOT4 has been implicated in metabolic syndromes and fatty acid-related disorders, emphasizing its role in maintaining peroxisomal and systemic lipid balance. Its enzymatic function supports metabolic adaptability during dietary shifts and stress conditions, underscoring its importance in lipid metabolism and cellular homeostasis.
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