Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) Antibody
292.5€ (80 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx025204
tested applications
ELISA, WB, IHC, IF/ICC
Description
ACOX1 is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/4000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15067 |
| Alias | AOX,ACOX,SCOX,MITCH,PALMCOX |
| Background | Antibody anti-ACOX1 |
| Status | RUO |
Descripción
Acyl-CoA oxidases (ACOXs) are crucial enzymes involved in the first step of peroxisomal β-oxidation, a pathway responsible for the breakdown of very-long-chain fatty acids (VLCFAs), branched-chain fatty acids, and bile acid intermediates. ACOXs catalyze the oxidation of acyl-CoA to trans-2-enoyl-CoA, producing hydrogen peroxide in the process. ACOX catalyzes the first step of the beta-oxidation pathway within peroxisomes. It oxidizes long-chain acyl-CoA molecules, removing two carbons from the fatty acid chain to produce trans-2-enoyl-CoA. This reaction involves the transfer of electrons to molecular oxygen, leading to the formation of hydrogen peroxide (H2O2). Fatty acid beta-oxidation is a crucial pathway for the catabolism of fatty acids, which are important sources of energy for cells. By breaking down fatty acids into acetyl-CoA units, beta-oxidation provides substrates for energy production through processes such as the citric acid cycle and oxidative phosphorylation. ACOX1 preferentially oxidizes straight-chain VLCFAs.
Related Products
Human ACOX1 (Peroxisomal acyl-coenzyme A oxidase 1) ELISA Kit
Ver Producto
ACOX1 antibody
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.
Ver Producto