Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) Antibody
312€ (60 µl)
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935106861
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name
Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx007121
tested applications
IHC, IF/ICC
Description
ACOX1 Antibody is a Rabbit Polyclonal Antibody against ACOX1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acyl Coenzyme A Oxidase 1, Palmitoyl (ACOX1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | IHC-P: 1/100 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15067 |
| Gene ID | 51 |
| NCBI Accession | NP_004026.2 |
| Alias | AOX,ACOX,SCOX,MITCH,PALMCOX |
| Background | Antibody anti-ACOX1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Acyl-CoA oxidases (ACOXs) are crucial enzymes involved in the first step of peroxisomal β-oxidation, a pathway responsible for the breakdown of very-long-chain fatty acids (VLCFAs), branched-chain fatty acids, and bile acid intermediates. ACOXs catalyze the oxidation of acyl-CoA to trans-2-enoyl-CoA, producing hydrogen peroxide in the process. ACOX catalyzes the first step of the beta-oxidation pathway within peroxisomes. It oxidizes long-chain acyl-CoA molecules, removing two carbons from the fatty acid chain to produce trans-2-enoyl-CoA. This reaction involves the transfer of electrons to molecular oxygen, leading to the formation of hydrogen peroxide (H2O2). Fatty acid beta-oxidation is a crucial pathway for the catabolism of fatty acids, which are important sources of energy for cells. By breaking down fatty acids into acetyl-CoA units, beta-oxidation provides substrates for energy production through processes such as the citric acid cycle and oxidative phosphorylation. ACOX1 preferentially oxidizes straight-chain VLCFAs.
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The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.
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