Acyl-CoA Thioesterase 2 (ACOT2) Antibody
637€ (100 µl)
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Name
Acyl-CoA Thioesterase 2 (ACOT2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx110801
Tested Applications
ELISA, WB, IHC
Description
Acyl-Coa Thioesterase 2 Antibody is a Rabbit Polyclonal antibody against Acyl-Coa Thioesterase 2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Acyl-CoA Thioesterase 2 (ACOT2) Immunogen: Human ACOT2. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49753 |
| Gene ID | 10965 |
| NCBI Accession | NP_006812.3, NM_006821.5 |
| OMIM | 609972 |
| Alias | MTE1,PTE2,CTE1A,PTE2A,CTE-IA,ZAP128 |
| Background | Antibody anti-ACOT2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ACOT2 is a mitochondrial enzyme that catalyzes the hydrolysis of acyl-CoA esters into free fatty acids and CoA, playing a pivotal role in mitochondrial fatty acid metabolism and energy regulation. It is highly expressed in energy-demanding tissues such as the heart, liver, and skeletal muscle, where it regulates the pool of acyl-CoA intermediates and ensures efficient β-oxidation. ACOT2 also serves as a key regulator of mitochondrial CoA homeostasis, preventing the accumulation of acyl-CoA esters that could inhibit mitochondrial enzymes. Its role extends to regulating lipid signaling molecules and providing precursors for membrane biosynthesis. Dysregulation of ACOT2 has been associated with metabolic dysfunctions, such as insulin resistance and mitochondrial disorders, reflecting its importance in maintaining energy balance and metabolic integrity. ACOT2’s mitochondrial localization and activity highlight its critical role in coordinating lipid utilization and energy production under various physiological conditions.
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