Acyl-CoA Thioesterase 2 (ACOT2) Antibody
52€ (10 µg)
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Name
Acyl-CoA Thioesterase 2 (ACOT2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx014149
Tested Applications
ELISA, WB
Description
Rabbit polyclonal antibody against ACOT2 protein. Immunogen region is Internal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Acyl-CoA Thioesterase 2 (ACOT2) Immunogen: The antiserum was produced against synthesized peptide derived from internal of human ACOT2. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49753 |
| Alias | MTE1,PTE2,CTE1A,PTE2A,CTE-IA,ZAP128 |
| Background | Antibody anti-ACOT2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ACOT2 is a mitochondrial enzyme that catalyzes the hydrolysis of acyl-CoA esters into free fatty acids and CoA, playing a pivotal role in mitochondrial fatty acid metabolism and energy regulation. It is highly expressed in energy-demanding tissues such as the heart, liver, and skeletal muscle, where it regulates the pool of acyl-CoA intermediates and ensures efficient β-oxidation. ACOT2 also serves as a key regulator of mitochondrial CoA homeostasis, preventing the accumulation of acyl-CoA esters that could inhibit mitochondrial enzymes. Its role extends to regulating lipid signaling molecules and providing precursors for membrane biosynthesis. Dysregulation of ACOT2 has been associated with metabolic dysfunctions, such as insulin resistance and mitochondrial disorders, reflecting its importance in maintaining energy balance and metabolic integrity. ACOT2’s mitochondrial localization and activity highlight its critical role in coordinating lipid utilization and energy production under various physiological conditions.
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