Acyl-CoA Thioesterase 11 (ACOT11) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
Acyl-CoA Thioesterase 11 (ACOT11) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037874
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ACOT11 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acyl-CoA Thioesterase 11 (ACOT11) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_015547 |
| Alias | BFIT,THEA,THEM1,STARD14 |
| Background | Antibody anti-ACOT11 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ACOT11, also known as BFIT (Brown Fat-Inducible Thioesterase), is a cytosolic enzyme involved in the hydrolysis of medium- and long-chain acyl-CoA esters, with a specific role in thermogenesis and energy expenditure. It is highly expressed in brown adipose tissue, where it regulates fatty acid mobilization and provides substrates for heat production through mitochondrial uncoupling. ACOT11 plays a crucial role in lipid metabolism during periods of cold exposure or metabolic stress, ensuring an adequate supply of free fatty acids for β-oxidation and thermogenic activity. In addition to its role in brown fat, ACOT11 is expressed in other tissues, where it contributes to lipid signaling and metabolic homeostasis. Dysregulation of ACOT11 has been implicated in metabolic syndromes such as obesity and insulin resistance, making it a potential target for therapies aimed at enhancing energy expenditure and combating metabolic diseases.
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This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants.
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