Acyl-CoA Synthetase Short-Chain Family Member 1 (ACSS1) Antibody
221€ (50 µg)
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Name
Acyl-CoA Synthetase Short-Chain Family Member 1 (ACSS1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx325920
Tested Applications
ELISA, WB, IHC
Description
ACSS1 Antibody is a Rabbit Polyclonal against ACSS1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Acyl-CoA Synthetase Short-Chain Family Member 1 (ACSS1) Immunogen: Synthesized peptide derived from the C-terminal region of human ACSS1. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/40000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NUB1 |
| Gene ID | 84532 |
| Alias | ACAS2L,ACECS1,AceCS2L |
| Background | Antibody anti-ACSS1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ACSS1 is a mitochondrial enzyme that activates short-chain fatty acids, primarily acetate, by converting them into acetyl-CoA, which serves as a substrate for the tricarboxylic acid (TCA) cycle, lipid synthesis, and protein acetylation. It is expressed predominantly in tissues with high metabolic demand, such as the liver, heart, and skeletal muscle, where it facilitates energy production and metabolic flexibility. ACSS1 plays a pivotal role in maintaining energy homeostasis during fasting or ketogenic states by metabolizing acetate derived from dietary sources or fatty acid oxidation. Dysregulation of ACSS1 has been linked to metabolic disorders, such as obesity and diabetes, where impaired acetate metabolism affects energy balance and lipid biosynthesis. Its role in mitochondrial acetyl-CoA production underscores its importance in supporting cellular metabolism and adapting to changes in energy availability.
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